Cancer Therapy: Clinical ChemopreventionofHeadandNeckCancer bySimultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies

نویسندگان

  • Dong M. Shin
  • Hongzheng Zhang
  • Nabil F. Saba
  • Amy Y. Chen
  • Sreenivas Nannapaneni
  • Melinda Lewis
  • Gabriel Sica
  • Scott Kono
  • Johann C. Brandes
  • William J. Grist
  • Rachel Moreno-Williams
  • Jonathan J. Beitler
  • Sufi M. Thomas
  • Zhengjia Chen
  • Hyung Ju C. Shin
  • Jennifer R. Grandis
  • Fadlo R. Khuri
  • Zhuo Georgia Chen
چکیده

Purpose:We investigated the efficacy and underlyingmolecularmechanism of a novel chemopreventive strategy combining EGF receptor (EGFR) tyrosine kinase inhibitor (TKI) with cyclooxygenase-2 inhibitor

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تاریخ انتشار 2013